Buy Simponi for patients that have inflammation caused by arthritis. With the generic name golimumab, this medicine is used mostly to treat rheumatoid arthritis and ankylosing spondylitis in adults.
Who benefits the most from Simponi
This treatment is an anti0inflammatory, meaning it will benefit mostly those who have inflamed joints or areas of their body due to various kinds of arthritis and even colitis.
Ailments Treated with Simponi
These are some of the ailments that this treatment is indicated for:
- Rheumatoid arthritis
- Juvenile idiopathic arthritis
- Psoriatic arthritis
- Axial spondyloarthritis
- No-radiographic axial spondylarthritis
- Ulcerative colitis
How does Simponi work?
The active ingredient in Simponi known as golimumab, and it is a monoclonal antibody. It is a kind of protein which has been specifically developed to recognize and connect itself to a specific structure called an antigen, found inside the body. Simponi was particularly designed to attach to and block called tumor necrosis factor alpha, also known as TNF-a. This substance is part of what’s causing the inflammation, and is actually found in quite large amounts in patients that have the ailments this medicine is supposed to treat. By blocking the TNF-a, this treatment significantly reduced inflammation, as well as other symptoms of those aforementioned diseases.
Simponi is at times given via infusion into a vein. The healthcare provider or doctor will be doing this procedure once every four to eight weeks, depending on the doctor’s recommendation. The medication can also be injected under the skin every 2 to 4 weeks, and with this the patient themselves can be taught to administer it. It should be noted that every session a different part of the body should be targeted, never twice in the same place in a row.
For adult dose in ankylosing spondylitis
50mg subcutaneously once a month
For psoriatic arthritis
50mg subcutaneously once a month
For ulcerative colitis
200mg initial dose subcutaneously, followed by 100mg 2 weeks later. Maintain 100mg subcutaneously every 4 weeks afterwards
For rheumatoid arthritis
50mg subcutaneously once a month or 2mg per kg IV infusion over 30 minutes for first session, then same amount in second session 4 weeks later. Same amount every 8 weeks after second session.
How long does Simponi last?
It can sometimes take 2 weeks before the effects can be felt. Some patients notice it immediately after the first dose, while others may take longer. For any significant benefit, it usually occurs around 4 to 12 weeks after.
Patients with hypersensitivities to any of Simponi’s components should avoid it. Those who have active infections or opportunistic infections should not use this either, and neither should those with moderate or severe heart failure. For complete list of contraindications and warnings, please refer to package leaflet.
Other Side Effects
These are signs of infections and if the patient has them, they should immediately call the doctor
- Fever, chills, night sweats
- Weight loss
- Cough, bloody mucus, shortness of breath
- Increased urination
- Skin sores, warmth, pain, redness
Common side effects include:
- High blood pressure
- Infections, cold, or flu symptoms
For a full list, please check the package leaflet.
When using this medication, patients should not accept live vaccines, which include but are not limited to measles, rubella, mumps, typhoid, yellow fever, rotavirus, and shingles vaccines.
Cost of Simponi
These are the average prices for Simponi:
100mg/1ml solution for pre-filled pen = $6217
50mg/0.5ml solution for pre-filled pen = $5407
50mg/0.5ml solution for pre-filled syringes = $5407
In clinical studies, Simponi has shown to give 55% of patients around 20% reduction of symptoms, and those who took the treatment also reported greater ease and improvements in performing normal everyday tasks such as eating, walking, and dressing after 24 weeks. X-rays two years after treatment also showed significantly less joint damage in patients who received Simponi.
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